HDAC Inhibitor and Proteasome Inhibitor Induce Cleavage and Exosome-Mediated Secretion of HSP90 in Mouse Pluripotent Stem Cells

HDAC inhibitors and proteasome inhibitors induced heat shock protein 90 (HSP90) cleavage in the mouse ESC line R1, and the cleaved HSP90 was barely found in the cells and instead secreted out of the cells through the exosome.