STAT1 Is Essential for HSC Function and Maintains MHCIIhi Stem Cells that Resists Myeloablation and Neoplastic Expansion

The authors showed that loss of STAT1 altered the steady state hematopoietic stem/progenitor cell landscape, impaired HSC function in transplantation assays, delayed blood cell regeneration following myeloablation, and disrupted molecular programs which protect HSCs including control of quiescence.

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