Performance of Islets of Langerhans Conformally Coated via an Emulsion Cross-Linking Method in Diabetic Rodents and Nonhuman Primates

The authors developed and validated an augmented conformal coating (CC) method that achieved hydrogel CCs around islets at physiological pH for improved cytocompatibility, with PEG hydrogels for increased biocompatibility and with fivefold increase in encapsulation throughput for enhanced scalability.