ZMYND8 Is a Master Regulator of 27-Hydroxycholesterol that Promotes Tumorigenicity of Breast Cancer Stem Cells

Using genetic mouse mammary tumor and human breast cancer models, researchers showed that the histone reader ZMYND8 was selectively expressed in breast cancer stem cells (BCSCs) and promoted epithelial-mesenchymal transition, BCSC maintenance and self-renewal, and oncogenic transformation through its epigenetic functions, leading to breast tumor initiation.