Efficacy of Cancer-Specific Anti-Podoplanin CAR-T Cells and Oncolytic Herpes Virus G47Δ Combination Therapy against Glioblastoma

LpMab-2 (Lp2)-CAR transduced T cells (Lp2-CAR-T) specifically targeted podoplanin (PDPN)-expressing glioma cells, while sparing the PDPN-expressing normal cells. Lp2-CAR-T also killed patient-derived glioma stem cells, demonstrating its clinical potential against glioblastoma.