NewslettersMuscle Cell NewsInactivation of Sirt6 Ameliorates Muscular Dystrophy in Mdx Mice by Releasing Suppression of Utrophin ExpressionBy lbeveridge - July 25, 20220126Scientists demonstrated that SIRT6 deacetylated H3K56ac in myofibers to suppress expression of utrophin, a dystrophin-related protein stabilizing the sarcolemma in absence of dystrophin.[Nature Communications]Abstract