Inactivation of Sirt6 Ameliorates Muscular Dystrophy in Mdx Mice by Releasing Suppression of Utrophin Expression

Scientists demonstrated that SIRT6 deacetylated H3K56ac in myofibers to suppress expression of utrophin, a dystrophin-related protein stabilizing the sarcolemma in absence of dystrophin.
[Nature Communications]
Abstract
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