Tumor-Promoting Properties of Karyopherin β1 in Melanoma by Stabilizing Ras-GTPase-Activating Protein SH3 Domain-Binding Protein 1

Researchers demonstrated that karyopherin β1 (KPNB1) knockdown significantly retarded the growth and metastasis of melanoma cells in vitro and in vivo, and increased their sensitivity towards the anti-tumor drug cisplatin.