TNK2/ACK1-Mediated Phosphorylation of ATP5F1A (ATP Synthase F1 Subunit Alpha) Selectively Augments Survival of Prostate Cancer While Engendering Mitochondrial Vulnerability

Researchers demonstrated that a non-receptor tyrosine kinase, tyrosine kinase non receptor 2 (TNK2)/ACK1, phosphorylated ATP synthase F1 subunit alpha (ATP5F1A) at Tyr243 and Tyr24 that not only increased the stability of complex V, but also increased mitochondrial energy output in cancer cells.
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