Impaired Proteolysis of Non-Canonical RAS Proteins Drives Clonal Hematopoietic Transformation

The authors identified that loss of LZTR1, or leukemia-associated mutants in the LZTR1 substrate and RAS GTPase RIT1 which escaped degradation, drove hematopoietic stem cell expansion and leukemia in vivo.
[Cancer Discovery]

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