NewslettersCancer Stem Cell NewsImpaired Proteolysis of Non-Canonical RAS Proteins Drives Clonal Hematopoietic TransformationBy lbeveridge - August 1, 20220158The authors identified that loss of LZTR1, or leukemia-associated mutants in the LZTR1 substrate and RAS GTPase RIT1 which escaped degradation, drove hematopoietic stem cell expansion and leukemia in vivo.[Cancer Discovery]Abstract