N6-Adenomethylation of GsdmC Is Essential for Lgr5+ Stem Cell Survival to Maintain Normal Colonic Epithelial Morphogenesis

Mettl14 ablation triggered apoptosis that depleted Lgr5+ stem cells and disrupted colonic organoid growth and differentiation, whereas the inhibition of apoptosis rescued Mettl14-deleted mice and organoids.
[Developmental Cell]
AbstractGraphical Abstract
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