Reprogramming Adipose Mesenchymal Stem Cells into Islet β-Cells for the Treatment of Canine Diabetes Mellitus

In this study, Pbx1, Rfx3, Pdx1, Ngn3, Pax4 and MafA were used to form a six-gene combination to efficiently reprogram adipose MSCs (aMSCs) into reprogrammed aMSCs-derived islet β-cells.