Triple-Negative Breast Cancer Metastasis Involves Complex Epithelial-Mesenchymal Transition Dynamics and Requires Vimentin

The authors demonstrated that spontaneous triple-negative breast cancer tumors from a genetically engineered mouse model, multiple patient-derived xenografts, and archival patient samples exhibited large populations in vivo of hybrid E/M cells that lead invasion ex vivo while expressing both epithelial and mesenchymal characteristics.
[Science Translational Medicine]
Abstract
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