Tumor-Polarized GPX3⁺ AT2 Lung Epithelial Cells Promote Premetastatic Niche Formation

By single-cell sequencing, investigators identified a tumor-polarized subpopulation of alveolar type 2 (AT2) epithelial cells with increased expression of glutathione peroxidase 3 (GPX3) and high production of interleukin-10 in the premetastatic niche.