Preclinical Assessment of Antigen-Specific Chimeric Antigen Receptor Regulatory T Cells for Use in Solid Organ Transplantation

Scientists reported the preclinical characterization of Tregs transduced with a human leukocyte antigen (HLA)-A*02 CAR lentiviral vector designated to induce immunosuppression of allograft-specific effector T cells in HLA-A*02-negative recipients of HLA-A*02-positive transplants.