Angiopoietin-2 Inhibition Attenuates Kidney Fibrosis by Hindering Chemokine C-C Motif Ligand 2 Expression and Apoptosis of Endothelial Cells.

Researchers found in a cohort of 319 patients with chronic kidney disease that plasma angiopoietin-2 and angiopoietin-2/angiopoietin-1 ratios were positively associated with the development of kidney failure.