Generation of T Cell-Receptor-Negative CD8αβ-Positive CAR T Cells from T Cell-Derived Induced Pluripotent Stem Cells

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Investigators showed that the premature expression of the T cell receptor (TCR) or a constitutively expressed CAR in T cell-derived induced pluripotent stem cells promoted the acquisition of an innate phenotype, which could be averted by disabling the TCR and relying on the CAR to drive differentiation.
[Nature Biomedical Engineering]
Abstract