Cadherin-26 Amplifies Airway Epithelial IL-4 Receptor Signaling in Asthma

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In cultured human bronchial epithelial cells, cadherin-26 knockdown inhibited IL-13 induced IL-4Rα and IL-13Rα1 upregulation and suppressed downstream Jak1 and Stat6 phosphorylation.
[American Journal of Respiratory Cell and Molecular Biology]
Abstract