New Diterpenes From the Marine Sponge Spongionella sp. Overcome Drug Resistance in Prostate Cancer by Inhibition of P-Glycoprotein

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Researchers discovered that spongionellol A and 15,16-dideoxy-15α,17β-dihydroxy-15,17-oxidospongian-16-carboxylate-15,17-diacetate exhibited high activity and selectivity in human prostate cancer cells, including cells resistant to hormonal therapy and docetaxel.
[Scientific Reports]
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