LACC1 Bridges NOS2 and Polyamine Metabolism in Inflammatory Macrophages

Scientists elucidated a shared biochemical function of laccase domain-containing 1 (LACC1) in mice and humans, converting L-citrulline to L-ornithine and isocyanic acid and serving as a bridge between proinflammatory nitric oxide synthase (NOS2) and polyamine immunometabolism.