IGF-Binding Proteins Secreted by Cancer-Associated Fibroblasts Induce Context-Dependent Drug Sensitization of Lung Cancer Cells

Gene expression and secretome analyses of cancer-associated fibroblasts and normal lung–associated fibroblasts revealed differential abundance of insulin-like growth factors (IGFs) and IGF-binding proteins, which promoted or inhibited, respectively, signaling by the receptor IGF1R and the kinase FAK.