Radiation Enhances the Efficacy of EGFR-Targeted CAR-T Cells against Triple-Negative Breast Cancer by Activating NF-κB/Icam1 Signaling

Mechanistically, radiation significantly increased Icam1 expression on TNBC cells via activating nuclear factor κB (NF-κB) signaling, thereby promoting chimeric antigen receptor T cell infiltration and killing.