Ectopic JAK–STAT Activation Enables the Transition to a Stem-Like and Multilineage State Conferring AR-Targeted Therapy Resistance

Scientists revealed that Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signaling was a crucial executor in promoting lineage plasticity-driven androgen receptor (AR)-targeted therapy resistance in prostate cancer.
[Nature Cancer]
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