3D Matrix Promotes Cell Dedifferentiation into Colorectal Cancer Stem Cells via Integrin/Cytoskeleton/Glycolysis Signaling

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The 3D extracellular matrix could mediate cytoskeletal F-actin bundling through biomechanical force associated receptors integrin β1, contributing to the release of E3 ligase Tripartite motif protein 11 from cytoskeleton and degradation of the glycolytic rate-limiting enzyme phosphofructokinase.
[Cancer Science]
Abstract