Interleukin-1 Contributes to Clonal Expansion and Progression of Bone Marrow Fibrosis in JAK2V617F-Induced Myeloproliferative Neoplasm

Investigators showed that genetic deletion of IL-1 receptor 1 normalized peripheral blood counts, reduced splenomegaly and ameliorates bone marrow fibrosis in homozygous Jak2V617F mouse model of myelofibrosis.