Escin Suppresses Immune Cell Infiltration and Selectively Modulates Nrf2/HO-1, TNF-α/JNK, and IL-22/STAT3 Signaling Pathways in Concanavalin A-Induced Autoimmune Hepatitis in Mice

Scientists investigated the possible protective effect of escin, the active constituent of a natural mixture of triterpene saponin glycoside, against immune-mediated hepatitis driven by concanavalin A and to elucidate its possible underlying mechanisms.

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