Long-Term Follow-Up of Autologous Peripheral Blood Hematopoietic Stem Cell Transplantation for Refractory Lupus Nephritis—A Series Study of 20 Patients
22 patients with lupus nephritis refractory to immunosuppressive therapy were enrolled. 20 patients were examined closely and two cases died within 100 days after autologous hematopoietic cell transplantation.
[Bellerophon Therapeutics, Inc.] Bellerophon Therapeutics, Inc. announced that the FDA has accepted the company’s proposal to reduce the study size for its ongoing registrational REBUILD Phase III trial of INOpulse® for the treatment of fibrotic interstitial lung disease.
[Nature Communications] Researchers determined transcriptional changes of idiopathic pulmonary fibrosis-airway basal cells and their potential profibrotic properties using a 3D culture system and novel mouse xenograft models.
[JCI Insight] Investigators found that growth factor–β1-mediated upregulation of UHRF1 repressed Beclin1 via promoter methylation induction which resulted in fibroblast activation and lung fibrosis both in vitro and in vivo.