Hox-Driven Conditional Immortalization of Myeloid and Lymphoid Progenitors: Uses, Advantages, and Future Potential

Investigators review the use of Hoxb8 and Hoxa9 as hematopoietic regulators to conditionally immortalize murine hematopoietic progenitor cells which retained their ability to differentiate into many functional immune cell types including macrophages, neutrophils, basophils, osteoclasts, eosinophils, and dendritic cells.