Spike Mutation Resilient scFv76 Antibody Counteracts SARS-CoV-2 Lung Damage Upon Aerosol Delivery

Researchers showed that scFv76 also neutralizes infectivity and fusogenic activity of Omicron BA.1 and BA.2 variants. Cryo-EM analysis revealed that scFv76 bound to a well-conserved SARS-CoV-2 spike epitope, providing the structural basis for its broad-spectrum activity.