Transcription and Splicing Regulation by NLRC5 Shape the Interferon Response in Human Pancreatic β Cells

Investigators observed by bulk and single-cell RNA sequencing that exposure of human induced pluripotent-derived islet-like cells to IFNα induced the expression of HLA class I, and of other genes involved in antigen presentation, including the transcriptional activator NLRC5.
[Science Advances]
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