Cancer Stem Cells Induced by Chronic Stimulation with Prostaglandin E2 Exhibited Constitutively Activated PI3K Axis

Investigators assessed prostaglandin E2 (PGE2) as a candidate for the ability to induce CSCs from iPSCs, and chronic stimulation of the receptors EP-2/4 by PGE2 was supposed to induce CSCs from iPSCs through epigenetic effect.