Single-Cell Transcriptome Reveals Cellular Hierarchies and Guides P-EMT-Targeted Trial in Skull Base Chordoma

Combining radiated UM-Chor1 RNA-seq data and in vitro validation, researchers found clusters of stem-like skull base chordoma cells were marked by cathepsin L, a gene involved in the packaging of telomere ends, and which may be responsible for radioresistance.