T Cell Cytoskeletal Forces Shape Synapse Topography for Targeted Lysis via Membrane Curvature Bias of Perforin

Investigators demonstrated murine and human T cell-mediated cytotoxicity to be a highly tuned mechano-biochemical system, in which the forces that polarized lytic granules locally bended the synaptic membrane to favor the unidirectional perforation of the target cell.
[Developmental Cell]
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