Replication-Competent HIV-1 in Human Alveolar Macrophages and Monocytes Despite Nucleotide Pools with Elevated dUTP

As compared to in vitro differentiated monocyte derived macrophages, alveolar macrophages from normal donors had sixfold lower levels of dTTP and a sixfold increased dUTP/dTTP, indicating a highly restrictive dNTP pool for reverse transcription.