Parkinson-Causing Mutations in LRRK2 Impair the Physiological Tetramerization of Endogenous α-Synuclein in Human Neurons

Patient neurons carrying G2019S, the most prevalent LRRK2 mutation, or R1441C each had decreased T:M ratios and pSer129 hyperphosphorylation of their endogenous αSyn along with increased phosphorylation of Rab10, a widely reported substrate of LRRK2 kinase activity.