Protective alpha1-Antitrypsin Effects in Autoimmune Vasculitis Are Compromised by Methionine Oxidation

Plasma and blood neutrophils were assessed for PR3 and AAT. Wild-type, mutant, and oxidation-resistant AAT species were produced to characterize AAT-PR3 interactions by flow cytometry, immunoblotting, FRET assays, and surface plasmon resonance measurements.
[Journal of Clinical Investigation]
AbstractGraphical Abstract

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