Colorectal Cancer Organoid Models Uncover Oxaliplatin-Resistant Mechanisms at Single Cell Resolution

The authors established two strains of patient-derived organoids (PDOs) selected from oxaliplatin-resistant and treatment-naïve CRC patients. To dissect the drug-resistant mechanisms, these colorectal cancer-PDOs were subjected to single-cell RNA sequencing.
[Cellular Oncology]
Abstract
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