Wnt5a/B-Catenin Axis Is Involved in the Downregulation of AT2 Lineage by PAI-1

Elevated PAI-1 level suppressed organoid number, development efficiency, and total surface area in vitro. Anti-PAI-1 neutralizing antibody restored organoid number, proliferation and differentiation of AT2 cells, and β-catenin level in organoids.
[American Journal of Physiology-Lung Cellular and Molecular Physiology]
Abstract
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