CYCLIN K Down-Regulation Induces Androgen Receptor Gene Intronic Polyadenylation, Variant Expression and PARP Inhibitor Vulnerability in Castration-Resistant Prostate Cancer

The authors demonstrated that pharmacological inhibition or genetic inactivation of CDK12 induces androgen receptor (AR) gene intronic polyadenylation intronic polyadenylation usage, AR-variant expression, and prostate cancer cell resistance to the antiandrogen enzalutamide.