PRC2-Indepdendent Actions of H3.3K27M in Embryonic Stem Cell Differentiation

The authors studied the immediate, genome-wide consequences of the H3.3K27M mutation independent of Polycomb Repressor Complex 2 (PRC2) activity. They developed Doxycycline-inducible mouse ESCs carrying a single extra copy of WT-H3.3, H3.3K27M, and H3.3K27L all fused to HA.
[Nucleic Acids Research]
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