Passage Number Affects Differentiation of Sensory Neurons from Human Induced Pluripotent Stem Cells

Scientists investigated the effect of passage number on iPSC differentiation to optimize the generation of sensory neurons (iPSC-dSNs). Three iPSC lines reprogrammed from the peripheral blood of three donors were differentiated into iPSC-dSNs at passage numbers within each of the following ranges: 5–10, 20–26, and 30–38.