Biomaterials and Tissue Engineering Approaches Using Glycosaminoglycans for Tissue Repair: Lessons Learned from the Native Extracellular Matrix
Scientists provide an overview of native glycosaminoglycans, their structure, and properties, specifically their interaction with proteins, their effect on cell behavior, and their mechanical role in the ECM.
[Molecular Psychiatry] 1275 immune-related genes were curated and their expression changes investigated in 2467 postmortem brains of controls and patients with six major brain disorders, including schizophrenia, bipolar disorder, autism spectrum disorder, major depressive disorder, Alzheimer’s disease, and Parkinson’s disease.
[Signal Transduction and Targeted Therapy] Investigators systemically analyzed lung pathogenesis in SARS-CoV-2- and its delta variant-infected humanized CD147 transgenic mice. Histopathology and Transmission Electron Microscopy revealed inflammation, fibroblast expansion and pronounced fibrotic remodeling in SARS-CoV-2-infected lungs.