DNA Sensor Associated Type I Interferon Signaling Is Increased in Ulcerative Colitis and Induces JAK-Dependent Inflammatory Cell Death in Colonic Organoids

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The effects of type I IFN, IFN-γ, and TNF-α on gene expression, cytokine production and cell death were investigated in human colonic organoids.
[American Journal of Physiology-Gastrointestinal and Liver Physiology]
Abstract