Liposomal UHRF1 siRNA Shows Lung Fibrosis Treatment Potential by Regulating Fibroblast Activation

Investigators found that growth factor–β1-mediated upregulation of UHRF1 repressed Beclin1 via promoter methylation induction which resulted in fibroblast activation and lung fibrosis both in vitro and in vivo.
[JCI Insight]
AbstractGraphical Abstract

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