Inhibiting ALK-TOPK Signaling Pathway Promotes Cell Apoptosis of ALK-Positive NSCLC

Researchers discovered that T-LAK cell-oriented protein kinase (TOPK) was highly expressed in anaplastic lymphoma kinase (ALK)-positive NSCLC. Phosphorylation of TOPK by ALK was found to inhibit enhanced apoptosis of ALK-positive NSCLC cells, providing novel treatment strategies.