Atypical Induction of HIF-1α Expression by Pericellular Notch1 Signaling Suffices for the Malignancy of Glioblastoma Multiforme Cells

The expression of HIF-1α was significantly elevated in highly dense glioblastoma cells, even under non-hypoxic conditions. Atypical HIF-1α expression was associated with the Notch1 signaling pathway in both glioblastoma and glioblastoma stem cells.