High Throughput-Screening of Native Herbal Compounds Identifies Taccaoside a as a Cytotoxic Compound that Mediates RAS Signaling in Cancer Stem Cells

Several putative cytotoxic compounds were evaluated for their cytotoxic effects on glioma stem cells, cancer cell lines, and immortalized cells using a variety of methods to study cell proliferation, cell death, DNA damage, mitochondrial membrane changes, and tumor formation in vitro.