DHODH Inhibition Impedes Glioma Stem Cell Proliferation, Induces DNA Damage, and Prolongs Survival in Orthotopic Glioblastoma Xenografts

Researchers demonstrated that glioma stem cells (GSCs) lacking epidermal growth factor receptor (EGFR) amplification are exquisitely sensitive to de novo pyrimidine synthesis perturbations, while GSCs that amplify EGFR were utterly resistant.