Intestinal Toxicity to CTLA-4 Blockade Driven by IL-6 and Myeloid Infiltration

Scientists found αCTLA-4 drove increased inflammation and colonic tissue damage in mice with genetic predisposition to intestinal inflammation, acute gastrointestinal infection, transplantation with a dysbiotic fecal microbiome, or dextran sodium sulfate administration.
[Journal of Experimental Medicine]

Stay up-to-date with your field!

Subscribe for free weekly science newsletters.

Related News