Intestinal Toxicity to CTLA-4 Blockade Driven by IL-6 and Myeloid Infiltration

Scientists found αCTLA-4 drove increased inflammation and colonic tissue damage in mice with genetic predisposition to intestinal inflammation, acute gastrointestinal infection, transplantation with a dysbiotic fecal microbiome, or dextran sodium sulfate administration.
[Journal of Experimental Medicine]
Abstract
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