The Transcriptional Terminator XRN2 and the RNA-Binding Protein Sam68 Link Alternative Polyadenylation to Cell Cycle Progression in Prostate Cancer

Investigators uncovered a mechanism of alternative polyadenylation regulation impinging on the interaction between the exonuclease XRN2 and the RNA-binding protein Sam68, whose increased expression in prostate cancer was promoted by the transcription factor MYC.
[Nature Structural & Molecular Biology]
Abstract
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