Design, Synthesis and Biological Evaluation Studies of Novel Anti-fibrosis Agents Bearing Sulfoxide Moiety

The authors designed and synthesized a series of novel small-molecule compounds through structural modification and fragment hybridization. Among them, a potential anti-fibrosis drug compd.1 was founded to be able to dose-dependently down-regulate ACTA2 and CTGF mRNA levels in human hepatic stellate cells treated with TGF-β.